Long-Lasting B- and T-Cell Responses in Virus-Like Particles to the Skin Induces Microneedle Delivery of H5N1 Influenza
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Published Ahead of Print 14 July 2010. 10.1128/CVI.00100-10. 2010, 17(9):1381. DOI: Clin. Vaccine Immunol. Sang-Moo Kang Donis, Mark R. Prausnitz, Richard W. Compans and Li-Mei Chen, Fu-Shi Quan, James C. Birchall, Ruben O. Pearton, C. Todd Davis, Dae-Goon Yoo, Kyoung-Mi Park, Jae-Min Song, Yeu-Chun Kim, Aleksandr S. Lipatov, Marc Mice Long-Lasting Band T-Cell Responses in Virus-Like Particles to the Skin Induces Microneedle Delivery of H5N1 Influenza
منابع مشابه
Long-term protective immunity from an influenza virus-like particle vaccine administered with a microneedle patch.
Skin vaccination with influenza virus-like particles (VLPs) using microneedles has been shown to induce protection similar to or better than that induced by intramuscular immunization. In this study, we examined the long-term protective efficacy of influenza (H1N1 A/PR/8/34) VLPs after skin vaccination using microneedle patches coated with the vaccine. Microneedle vaccination of mice in the ski...
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Abstract Background and Aims: Influenza A(H5N1) viruses circulating in animals might evolve and acquire the ability to spread from human to human and thus start a pandemic. Hemagglutinin (HA) has been shown to play a major role in binding of influenza virus to its target cell and the main neutralizing antibody responses elicit against this region. Recent studies have shown that...
متن کاملEnhanced memory responses to seasonal H1N1 influenza vaccination of the skin with the use of vaccine-coated microneedles.
BACKGROUND Morbidity and mortality due to influenza could be reduced by improved vaccination. METHODS To develop a novel skin delivery method that is simple and allows for easy self-administration, we prepared microneedle patches with stabilized influenza vaccine and investigated their protective immune responses. RESULTS Mice vaccinated with a single microneedle dose of trehalose-stabilize...
متن کاملIntradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization.
Influenza virus-like particles (VLPs) are a promising cell culture-based vaccine, and the skin is considered an attractive immunization site. In this study, we examined the immunogenicity and protective efficacy of influenza VLPs (H1N1 A/PR/8/34) after skin vaccination using vaccine dried on solid microneedle arrays. Coating of microneedles with influenza VLPs using an unstabilized formulation ...
متن کاملStabilization of Influenza Vaccine Enhances Protection by Microneedle Delivery in the Mouse Skin
BACKGROUND Simple and effective vaccine administration is particularly important for annually recommended influenza vaccination. We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficacy. METHODOLOGY/PRINCIPAL FINDINGS Solid microneedle arrays coated with inact...
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تاریخ انتشار 2010